Introduction of Laboratory of Reproductive Medicine
연구팀 소개
전원 석·박사 급 연구원으로 구성된 서울의료원 생식의학연구실은
난임 극복을 위해 끊임없이 연구하고 있으며,
25년 이상의 축적된 임상경험으로 어떠한 케이스에도 맞춤 대응할 수 있습니다.
과학과 생명이 만나는 곳,
그곳에서 우리는 기다립니다.
난임 시술에서 의료진만큼 중요한 역할을 하는 것이 바로 임상배아연구원의 역량입니다.
난자·정자 채취에서 배아생성, 이식, 동결보존 등 임상연구 업무는 체외수정 시술 성공을 좌우하는
중요한 과정입니다. 국내 유수 배아생성의료기관 출신으로 구성된 저희 연구팀은 난임 연구에 있어
최고의 기술력과 노하우를 보유하고 있습니다.
약력
- 이학박사
- 임상배아연구원, 책임연구원(Clinical Embryologist, Chief Lab. Director)
- 대한배아전문가협의회 회장
- 대한생식면역학회 부회장
- 대한생식의학회 상임이사, 임상배아연구위원장
- 대한생식의학회 심사위원
- 대한가임력보존학회 심사위원, 교육수련위원
- 대한남성과학회 학술위원
- 한국발생생물학회 이사
- 전) 제일의료재단 제일병원 생식의학연구실 실장
수상 경력
- KSRM-MERCK Award 피인용상, 대한생식의학회, 2020년
- Star Award, 미국불임학회(American Society for Reproductive Medicine),2015년
- 일문회학술상, 제일의료재단 제일병원, 2009년
- 李東熙학술상, 제일의료재단 제일병원, 2008년
- 학술상, 대한생식의학회(구, 대한불임학회), 2004년
특별 강연
- Semen Analysis from Embryologist’s Point of View. 19th Biennial Meeting of the Asia Pacific Society for Sexual Medicine & 40th Annual Meeting of Korean Society for Sexual Medicine and Andrology (APSSM & KSSMA). 2023년
- Endocrinology of Fallopian Tube. The 82th Korean Society for Reproductive Medicine (KSRM) Conference. 2022년
- Assisted Reproductive Technology – Now and Future, Laboratory Perspectives. 성신여자대학교 기초과학연구소 세미나. 2022년
- 임상배아연구원이 알아야 할 감염관리. 제19, 20차 대한배아전문가협의회 정기교육. 2021년
- 배아생성의료기관 실무자과정 배아생성의료기관 기관위원회 운영, 질병 관리청. 2020년
- Oocyte aging – Mechanisms and Treatment. The 77th Korean Society for Reproductive Medicine (KSRM) Conference. 2019년
- Minimizing Cryo-damage in Cryopreservation of Oocyte or Ovarian tissue. The 11th Korean Society Fertility Preservation (KSFP) Conference. 2018년
- Day 4 embryo quality assessment and ET. The 74th Korean Society for Reproductive Medicine (KSRM) Conference. 2018년
- Quality Control and problem solving in IVF laboratory. The 31th Korean Society for Assisted Reproduction (KOSCR) Conference. 2018년
- Current status of human embryo cryopreservation. The 31th Korean Society of Developmental Biology (KSDB) Annual meeting. 2012년
논문 발표
1. Ko, DS, Lee SH, Park CW, Lim CK. Birth of a healthy baby after preimplantation genetic diagnosis in a carrier of mucopolysaccharidosis type II: The first case in Korea. Clin Exp Reprod Med. 2019:46(4):206-210. DOI: https://doi.org/10.5653/cerm.2019.00094
2. Park YS, Lee SH, Choi HW, Lee HS, Lee JS, Seo JT. Abnormal Human Sperm Parameters Contribute to Sperm DNA fragmentation (SDF) in Men with Varicocele. World J Mens Health. 2018 Sep;36(3):239-247. doi: 10.5534/wjmh.180014. Epub 2018 Jul 30.
3. Lee SH, Park CW, Cheon YP, Lim CK. Potential of testicular sperm to support embryonic development to the blastocyst stage is comparable to that of ejaculated sperm. J Assist Reprod Genet. 2018 Jun;35(6):1103-1111
4. Lee SH, Park YS, Lim CK, Choi HW, An JH, Park CW, Lee HS, Lee JS, Seo JT. Paternal age as an independent factor does not affect embryo quality and pregnancy outcomes of testicular sperm extraction-intracytoplasmic sperm injection in azoospermia. Andrologia. 2018 Mar;50(2). doi: 10.1111/and.12864. Epub 2017 Jul 13.
5. Lee SH, Lee JH, Park YS, Yang KM, Lim CK. Comparison of clinical outcomes between in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in IVF-ICSI split insemination cycles. Clin Exp Reprod Med. 2017 Jun;44(2):96-104.
6. Choi HW, Park YS, Lee SH, Lim CK, Seo JT, and Yang KM. Effects of maternal age on embryo quality and pregnancy outcomes using testicular sperm with intracytoplasmic sperm injection. Clin Exp Reprod Med. 2016 Dec;43(4):221-227.
7. Park CW, Lee SH, Yang KM, Lee IH, Lim KT, Lee KH, Kim TJ. Cryopreservation of in vitro matured oocytes after ex vivo oocyte retrieval from gynecologic cancer patients undergoing radical surgery. Clin Exp Reprod Med. 2016 Jun;43(2):119-125.
8. Park YS, Lee SH, Lim CK, Cho JW, Yang KM, Seo JT. Effect of testicular spermatozoa on embryo quality and pregnancy in patients with non-obstructive azoospermia. Syst Biol Reprod Med. 2015;61(5):300–306.
9. Ko DS, Lee SH, Park DW, Yang KM, Lim CK. Pregnancy and fertilization potential of immature oocytes retrieved in intracytoplasmic sperm injection cycles. Clin Exp Reprod Med. 2015;42(3):118-125.
10. Kang HJ, Lee SH, Park YS, Lim CK, Ko DS, Yang KM, Park DW. Artificial oocyte activation in intracytoplasmic sperm injection cycles using testicular sperm in human in vitro fertilization. Clin Exp Reprod Med. 2015;42(2):45-50.
11. Park YS, Kim MK, Lim CK, Lee SH, Park DW, Seo JT, Yang KM. Efficacy of cryopreservation of embryos generated by intracytoplasmic sperm injection with spermatozoa from frozen testicular tissue. J Assist Reprod Genet. 2014;31(10):1331-1336.
12. Lee SH, Lee HS, Lim CK, Park YS, Yang KM, Park DW. Comparison of the clinical outcomes of day 4 and 5 embryo transfer cycles. Clin Exp Reprod Med. 2013;40(3):122-125.
13. Shin SB, Cho JW, Lee SH, Yang KM, Lim CK, Lee HS. Fertilization and pregnancy potential of immature oocytes from stimulated intracytoplasmic sperm injection cycles. Clin Exp Reprod Med. 2013;40(1):7-11.
14. Choi MH, Lee SH, Kim HO, Cha SH, Kim JY, Yang KM, Song IO, Koong MK, Kang IS, Park CW. Comparison of assisted reproductive technology outcomes in infertile women with polycystic ovary syndrome: In vitro maturation, GnRH agonist, and GnRH antagonist cycles. Clin Exp Reprod Med. 2012 Dec;39(4):166-171.
15. Shin MR, Choi HW, Kim MK, Lee SH, Lee HS, Lim CK. In vitro development and gene expression of frozen-thawed 8-cell stage mouse embryos following slow freezing or vitrification. Clin Exp Reprod Med. 2011;38(4):203-209.
16. Park YS, Kim MK, Lee SH, Cho JW, Song IO, Seo JT. Efficacy of testicular sperm chromatin condensation assay using aniline blue-eosin staining in the IVF-ET cycle. Clin Exp Reprod Med 2011;38(3):142-147 (pISSN 2233-8233/eISSN 2233-8241, 2011.09)
17. Kim MK, Lee SH, Choi SJ, Choi HW, Park DW, Lim CK, Song IO, Lee HS. Effect of Cryopreservation of Sibling 2PN Zygotes on Cumulative Delivery Rates in the Human IVF-ET Program. Korean J Reprod Med. 2010;37(4):329-338
18. Park YS, Choi SJ, Lee SH, Park DW, Lim CK, Jun JH, Koong MK, Park CW, Song IO, Seo JT. Comparative Results of Embryo Development and Clinical Pregnancy using Sperm Retrieved from Fresh and Frozen-thawed Testicular Tissue from Patients with Obstructive and Non-obstructive Azoospermia. Korean J Reprod Med. 2009;36(4):301-310.
19. Han SC, Park YS, Choi SJ, Lee SH, Hong SB, Lee HS, Lim CK, Song IO, Seo JT. Clinical Outcome of IVF-ET using Testicular Sperm Retrieved from Patients with Obstructive Azoospermia or Hypospermatogenesis. Korean J Reprod Med. 2009;36(1):55-61.
20. Lee SH, Song H, Park YS, Koong MK, Song IO, Jun JH. Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen-thawed cycles: potential paternal effects on pregnancy outcomes. Fertil Steril 2009;91(3):798-804 (ISSN 0015-0282, 2009.03)
21. Hong SB, Park DW, Shin MR, Choi SJ, Lee SH, Song IO, Jun JH. Efficacy of the Split Insemination Method Combining Conventional IVF and ICSI in Non-male Factor Infertile Couples with Normal Sperm parameters. Kor J Fertil Steril 2007 vol. 34(4), 305-312 (pISSN 2093-8896, 2007.12)
22. Choi SJ, Lee SH, Song IO, Koong MK, Kang IS, Jun JH. Efficacy of frozen-thawed ET in patients with old age or non-pregnant in fresh ET cycles. Kor J Fertil Steril 2006 vol. 33(4), 237-243 (ISSN 1226-2951, 2007.12)
23. Park YS, Lee SH, Han SC, Choi SJ, Jun JH, Koong MK, Seo JT. Fertilization, embryonic development, and pregnancy rate using fresh and frozen testicular sperm in hypospermatogenesis. Kor J Androl 2006;24(2):89-93 (ISSN 1229-1692, 2006.08)
24. Lee SH, Song SJ, Han SC, Byun HK, Seo JT, Park YS. Efficiency of Percoll gradient, PureSperm gradient, and swim up separation techniques in normal semen samples. Kor J Androl 2004;22(2):87-90 (ISSN 1229-1692, 2004.08)
25. Park YS, Lee SH, Song SJ, Jun JH, Koong MK, Seo JT. Influence of motility in fresh versus frozen testicular sperm IVF-ICSI outcome in men with obstructive azoospermia. Fertil Steril 2003;80(3):526-530 (ISSN 0015-0282, 2003.09)
26. Park YS, Lee SH, Han SH, Koong MK, Kim JW, Seo JT. Comparative analysis of sperm motility using Cell Soft System-3000 and Sperm Quality Analyzer-V. Kor J Fertil Steril 2003;30(2):165-169 (ISSN 1226-2951, 2003.06)
27. Han SC, Song SJ, Lee SH, Oh SH, Koong MK, Park YS. Light and electron microscopic observation in the frozen-thawed mouse testicular tissues. Kor J Fertil Steril 2003;30(2):127-133 (ISSN 1226-2951, 2003.06)
28. Lee SH, Park YS, Youm HW, Song GJ, Han SC, Bae IH. Effect of cryopreservation of the heat shock protein 90 expression in mouse ovarian tissue. Kor J Fertil Steril 2002;29(1):37-44 (ISSN 1226-2951, 2002.03)
학술대회 발표 (Presentations)
1. Park SY, Lee SH, Ko DS, Park S, Lee JK, Kim SM, Park CW, Lee JS, Lee HS, Seo JT (2018) Abnormal Sperm Parameters and Sperm DNA Fragmentation Affected by Advanced Age in Men with Varicocele (KSRM)
2. Park SY, Lee SH, Park S, Ko DS, Kim SM, Lee JK, Park CW, Lee JS, Lee HS, Seo JT (2018) Advanced Paternal Age Affect to Sperm Parameters and Sperm DNA Fragmentation (KSRM)
3. Choi SH, Kang MJ, Kim SM, Park S, Lee MH, Lim CK, Song IO, Park CW, Cheon YP, Lee SH (2018) Effect of trophectoderm biopsy on implantation potential of blastocysts (KSRM)
4. Park YS, Yoon SY, Lee JH, Lim CK, Song IO, Park CW, Lee HS, Lee JS, Seo JT, Lee SH (2018) Effects of advanced paternal age and maternal age on the outcome of ICSI using testicular sperm (ASRM)
5. Park SY, Yoon SY, Lee JH, Lim CK, Kim HO, Song IO, Park CW, Lee HS, Lee JS, Seo JT, Lee SH (2018) Effect of advanced paternal age on the outcome of ICSI using testicular sperm (KSRM)
6. Park SY, Lee JH, Yoon SY, Lim CK, Lee HS, Lee JS, Seo JT, Kim HO, Song IO, Park CW, Lee SH (2018) Paternal age and maternal age factor on the outcome of ICSI with testicular sperm (KSRM)
7. Han SC, Lim CK, Park YS, Song IO, Park CW, Seo JT, Lee SH (2017) Abnormal sperm parameters do not affect the pregnancy outcome after intrauterine insemination. Korean society for Reproductive Medicine (KSRM)
8. Park YS, Choi HW, Lee SH, Lee HS, Lee JS, Seo JT (2017) Defective sperm parameter can predict sperm DNA fragmentation (SDF). Korean society for Reproductive Medicine (KSRM)
9. Lee MH, Ko DS, Cho JW, Choi HW, Kang HJ, Lim CK, Cha SH, Park CW, Lee SH (2017) Multiple displacement amplification–based PGD test for fragile X syndrome. Korean society for Reproductive Medicine (KSRM)
10. Choi HW, Cho JW, Ko DS, Kang HJ, Lee MH, Yoon SY, Lee SH, Cha SH, Park CW, Lim CK (2017) Blastocyst stage versus cleavage stage biopsy for preimplantation genetic diagnosis of monogenic diseases. Korean society for Reproductive Medicine (KSRM)
11. Kang MJ, An JH, Lim CK, Park CW, Seo JT, Cheon YP, Lee SH (2017) Conventional In Vitro Fertilization should be considered preferentially in women over 40 years old without male factor. Korean society for Reproductive Medicine (KSRM)
12. Park S, Yoon SY, Lee JH, Lim CK, Kim MJ, Youn JS, Park CW, Lee SH (2017) Effects of micro-environment maintenance on human embryo development: comparison of standard incubator and bench-top incubator. Korean society for Reproductive Medicine (KSRM)
13. Choi SJ, Yoon SY, Hwang SJ, Han SC, Lim CK, Yoon M, Park CW, Lee SH (2017) Comparison of clinical outcomes of frozen-thawed embryo transfer cycles between pronuclear stage-thawed embryos and cleavage stage-thawed embryos. Korean society for Reproductive Medicine (KSRM)
14. Yoon SY, Lee JH, Park S, Kim HO, Song IO, Park CW, Lee SH (2017) More successful results could be expected when 3 or more embryos were transferred in woman ≥ 43 years old. Korean society for Reproductive Medicine (KSRM)
15. Yoon SY, Park DW, Han SC, Lee JH, Lee JH, Cha SH, Kim HO, Yang KM, Lee SH, (2016) Blastocyst re-expansion is a good predictor of clinical outcomes in frozen-thawed blastocyst transfer cycles. Korean society for Reproductive Medicine (KSRM)
16. Lee SH, Park YS, Park S, Lee JH, Lim CK, Gu HS, Park CW, Song IO, Yang KM (2016) Ejaculated and testicular sperm does not affect to the clinical outcomes in blastocyst transfer cycles after ICSI. Korean society for Reproductive Medicine (KSRM)
17. . Lee SH, Han SC, Yoon SY, Choi J, Lee JH , Lee JH, Park S, Lim CK, Park YS, Yang KM, Park DW (2015) Clinical pregnancy outcomes between cleavage stage embryo and morula stage embryo in frozen-thawed embryo transfer cycles. Pacific Society for Reproductive Medicine (PSRM)
18. . Lee SH, Park DW, Lim CK, Park YS, Yang KM, Lee HS (2012) Fertilization rate may be a predictor of implantation in ICSI cycles. Korean society for Reproductive Medicine (KSRM)
19. Lee SH, Park DW, Kang HJ, Lim CK, Yang KM, Lee HS (2013) Clinical pregnancy outcomes between cleavage stage embryo and blastocyst in frozen-thawed embryo transfer cycles. European Society of Human Reproduction and Embryology (ESHRE)
20. Lee SH, Lim CK, Shin MR, Park YS, Yang KM, Lee HS (2013) Comparison of Clinical Outcomes between Day 4 and 5 Embryo Transfer cycles - Is Day 4 As Good As Day 5 for Embryo Transfer? European Society of Human Reproduction and Embryology (ESHRE)
21. Lee SH, Kim MK, Han SC, Choi HW, Shin MR, Kang HJ, Yang KM, Lee HS (2011) Clinical outcomes of activated oocytes in fresh and frozen-thawed embryo transfer cycles. Korean society for Reproductive Medicine (KSRM)
22. Choi HW, Kang HJ, Shin MR, Kim MK, Lee SH, Koong MK, Song IO, Lim CK (2009) Developmental potential on day 3 fast-cleaving embryos and pregnancy outcome of fast-cleaving embryos transfer cycles. World Congress.
23. Lee SH, Park DW, Kim MK, Shin MR, Song IO, Lim CK (2009) Triploid zygote formation rate and ART outcomes. American Society of Reproductive Medicine (ASRM)
24. Lee SH, Kang HJ, Park DW, Choi HW, Hong SB, Kim HO, Park CW, Lim CK (2009) Comparison of clinical outcomes according to days of embryo transfer in ART cycles. World Congress
25. Lee SH, Park DW, Kim MK, Choi HW, Shin MR, Hong SB, Song IO, Koong MK, Lim CK (2008) Comparison of clinical outcomes in ART cycles of poor responders with normal sperm parameters between conventional IVF and ICSI. Korean Society for Reproductive Medicine(KSRM)
26. Lee SH, Song H, Choi HW, Bang KH, Moon MH, Koong MK, Song IO, Jun JH (2007) Comparison of clinical outcomes according to days of embryo transfer in ART cycles. Korean Society for Reproductive Medicine (KSRM)
27. Lee SH, Song H, Kim MK, Koong MK, Song IO, Jun JH (2007) Conventional IVF is as efficient as ICSI in ART cycles with low number of retrieved oocytes and normal sperm parameters. American Society of Reproductive Medicine (ASRM)
28. Lee SH, Song H, Choi SJ, H Choi W, Y Park S, Seo JT, Koong MK, Song IO, Jun JH (2007) Poor sperm quality influences clinical pregnancy outcome in ICSI: Potential paternal effects on pregnancy outcome. Korean society for Reproductive Medicine (KSRM)
29. Lee SH, Park DW, Choi SJ, Shin MR, I Song O, Jun JH (2007) Positive effect of physiological oxygen concentration on implantation and pregnancy outcomes in IVF-ET cycles. European Society of Human Reproduction and Embryology (ESHRE)
30. Lee SH, Choi SJ, Park YS, Song IO, Koong MK, Jun JH (2006) Defects of spermatogenesis effect on pregnancy and delivery outcomes in human IVF-ET program. Korean society for Reproductive Medicine (KSRM)
31. Lee SH, Choi SJ, Park YS, Seo JT, Song IO, Koong MK, Jun JH (2006) Effect of ejaculated sperm quality on clinical outcome in ICSI treatments. Pacific Rim Society for Fertility and Sterility (PRSFS)
32. Lee SH, Byun HK, Song SJ, Cheon KW, Koong MK, Park YS (2005) Comparison of NPB (nuclear precursor body) score, embryonic development and pregnancy outcomes between fresh- and frozen-thawed testicular sperm in obstructive azoospermic patients. American Society of Reproductive Medicine (ASRM)
서울의료원 생식의학연구실은
일반적인 인공수정, 체외수정 시술뿐만 아니라 미성숙난자체외성숙(In vitro maturation), 난소조직동결(Ovarian tissue cryopreservation), 난자동결보관(Oocyte cryopreservation), 고환정자채취술(Testicular sperm extraction, TESE), 착상전유전검사 포배기배아생검(Trophoectoderm biopsy for PGT), 성숙정자선별미세수정(Physiological intracytoplasmic sperm injection, PICSI) 등 다양한 기술력을 보유하고 있으며, 풍부한 임상경험을 바탕으로 여러분의 임신성공을 위해 최선을 다하고 있습니다.
AI 기반 실시간 배아 영상촬영 배양시스템(AI-based Time-lapse system), 난자방추사관찰시스템(Polscope), 정자 형태선별 미세수정시스템(Intracytoplasmic Morphologically selected Sperm Injection, IMSI), 미세 진동배양(Micro-vibration culture system) 등 최신 장비를 구비하여 최상의 배아를 생성하고 선별할 수 있는 시스템을 갖추고 있습니다.
또한 국내·외 주요 학술대회와 학술지에 연구 성과를 발표하고, 관련 전문가들과 최신 지견을 공유함으로써 난임 연구 발전에 기여하고 있습니다. 주기적인 자체 컨퍼런스 통해 전 세계 연구센터들의 우수한 연구 성과를 임상과 연구에 적용해나가고 있습니다.
국제적 수준의 HEPA filter
공조 시스템을 적용한 체외배양실
미세한 입자 및 세균의 제거를 위한
고성능 HEPA filter 공조 시스템을 365일 24시간 가동하여
체외배양실의 고청정도를 유지하고 있습니다.
최신 장비를 도입하여
최상의 배아 생성 및 선별시스템 구축
AI 기반 실시간 배아 영상촬영 시스템, 난자방추사관찰시스템,
정자 형태선별 미세수정시스템, 미세진동배양시스템과 같은
최첨단 장비를 구비하고 있습니다.
개인 맞춤형 시술을 할 수 있는
다양한 배양기술력 보유
미성숙난자의 체외성숙, 난소조직 동결, 난자 동결, 고환조직 정자 채취술,
착상전유전검사를 위한 포배기 배아 생검 등 다양한 기술력을 바탕으로
개인 맞춤형 시술을 제공하고 있습니다.
전원 석ㆍ박사급 연구원으로 구성되어
풍부한 경험과 노하우를 임상에 적용
임상 업무에 특화된 관련분야 석사, 박사출신 임상배아연구원들은
풍부한 경험과 지속적인 연구를 바탕으로 임신 성공에 힘씁니다.
주기적인 자체 컨퍼런스를 통해
전세계 우수 연구 성과와 최신 지견 공유
시험관아기시술 관련 전세계 연구센터들의 우수한 연구 성과를
공유하고 적용하며 끊임없이 노력하고 있습니다.